PDB
Can humans get myostatin?
Description. Myostatin-related muscle hypertrophy is a rare condition characterized by reduced body fat and increased muscle size. Affected individuals have up to twice the usual amount of muscle mass in their bodies. They also tend to have increased muscle strength.
Is myostatin natural?
2 Myostatin. Myostatin is produced by skeletal muscle. It is a highly conserved member of the TGF-β superfamily and myostatin knockout results in extensive skeletal muscle hypertrophy in mice (McPherron et al., 1997), cattle and humans (Rodgers and Garikipati, 2008).
What happens if you have no myostatin?
Lack of myostatin function results in the excessive growth of skeletal muscle, demonstrating the existence of a powerful mechanism to control muscle size in normal individuals (1).
Who has the myostatin gene?
Here we report that the myostatin gene is highly conserved among vertebrate species and that two breeds of cattle that are characterized by increased muscle mass (double muscling), Belgian Blue (3) and Piedmontese (4), have mutations in the myostatin coding sequence.
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