Background: Single nucleotide substitutions (SNS) in genetic codon are of prime importance due to their ability to alter an amino acid sequence as a result. Given the nature of genetic code, any SNS is expected to change the protein sequence randomly into any of the 64 possible codons. 15 июн. 2016 г.
How does substitution affect the amino acid sequence?
Substitution. It's always fascinated me how tiny changes in one's genome, like a simple substitution, can have such profound effects on human health. Changing a single nucleotide will change the amino acid sequence, which can impact how the protein it forms will look and act.
Does substitution mutation change the protein?
As with all mutations, a substitution mutation can drastically change the proteins created by an organism. The proteins responsible for reading DNA process the molecule in units of three base pairs at a time. These codons each specify a different amino acid.
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