The excretion of praziquantel occurs mainly through urine (60-80%) as well as bile and feces (15-35%) and is completed within 24 hours [1]. The elimination half-life of praziquantel in the human body is 1-2 hours [2], and after 24 hours, only a trace amount remains in the human body. 29 мар. 2013 г.
Does praziquantel need to be repeated?
Studies have suggested that a repeat dose of praziquantel, given 2 to 8 weeks after the first dose, can improve cure rates and reduce remaining intensity of infections in population-based programs.
How often can I use praziquantel?
How to use Praziquantel Tablet. Take this medication by mouth with a meal as directed by your doctor, usually 3 times a day (4 to 6 hours apart) for 1 day. Quickly swallow the tablets or tablet segments with a full glass of water (8 ounces or 240 milliliters).
What is the half-life of praziquantel?
CLINICAL PHARMACOLOGY After oral administration BILTRICIDE is rapidly absorbed (80%), subjected to a first pass effect, metabolized and eliminated by the kidneys. Maximal serum concentration is achieved 1-3 hours after dosing. The half-life of praziquantel in serum is 0.8-1.5 hours.
How long does praziquantel take to work in humans?
This medication should take effect within 1 to 2 hours; however, effects may not be noted outwardly and therefore laboratory tests may need to be done to evaluate this medication's effectiveness.
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