Salivation, vomiting, and diarrhea may occur in dogs or cats receiving this medication. This moderate-acting medication should stop working in a few days, although effects can be longer in pets with liver or kidney disease.
What are the side effects of fenbendazole in humans?
Fenbendazole binds beta-tubulin subunits of microtubules, interfering with their polymerization. Side effects include vomiting and diarrhea, although both are considered rare.
What happens when you take fenbendazole?
More than 50% of ingested fenbendazole is absorbed and metabolized in the liver, primarily to the active form, fenbendazole sulfoxide. Fenbendazole inhibits microtubule polymerization, and its efficacy as an anthelminthic results from its greater affinity for helminth tubulin than mammalian tubulin.
Is fenbendazole safe?
Fenbendazole, the active ingredient in Panacur and Safe-Guard, it is a benzimidazole dewormer which prevents cell division. It is generally considered a safe drug, toxicity only occurring at 100x overdoses and in exotic species. Fenbendazole isn't systemically absorbed and over 50% leaves the animal in feces.
Is fenbendazole hard on the liver?
We observed no relapse in hepatic disorder, and therefore we concluded that fenbendazole was the cause of liver dysfunction, although it remained a possibility that pembrolizumab in combination with fenbendazole may have enhanced hepatotoxicity.
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