With all this in mind, below are some of the most commonly used dog sedatives. Benadryl. Benadryl (Diphenhydramine) is not technically a sedative. . Acepromazine. Acepromazine causes sedation. . Gabapentin. . Trazodone. . Benzodiazepines (Valium, Xanax, Etc.) . Drugs for Long-term Anxiety Issues. . Injectable Sedation.
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