Botulism is a serious illness that affects the nervous system. It occurs when poisonous substances called botulinum toxins produce skeletal muscle paralysis. This paralysis can affect the muscles that help you move and breathe. 14 мая 2018 г.
What happens to the muscles in botulism?
Symptoms of botulism usually start with weakness of the muscles that control the eyes, face, mouth, and throat. This weakness may spread to the neck, arms, torso, and legs. Botulism also can weaken the muscles involved in breathing, which can lead to difficulty breathing and even death.
How does botulism cause muscle paralysis?
Intramuscular administration of botulinum toxin acts at the neuromuscular junction to cause muscle paralysis by inhibiting the release of acetylcholine from presynaptic motor neurons.
How does botulism affect the body?
Botulinum toxins are neurotoxic and therefore affect the nervous system. Foodborne botulism is characterized by descending, flaccid paralysis that can cause respiratory failure.
How does botulinum toxin affect the skeletal muscle?
Botulinum toxin works by blocking the release of acetylcholine from presynaptic motor neurons, and this chemical denervation causes a cascade of downstream events in the muscle thus causing muscle paralysis16.
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