Botulinum toxin causes weakness and loss of muscle tone because it blocks the nerve ending's ability to signal the linked muscle to contract. The bacterium C.
How does botulism affect the muscular system?
Botulism is a serious illness that affects the nervous system. It occurs when poisonous substances called botulinum toxins produce skeletal muscle paralysis. This paralysis can affect the muscles that help you move and breathe. Botulism is rare.
How does botulinum toxin cause muscle paralysis?
Intramuscular administration of botulinum toxin acts at the neuromuscular junction to cause muscle paralysis by inhibiting the release of acetylcholine from presynaptic motor neurons.
Why does botulism cause flaccid paralysis?
The flaccid paralysis of botulism is the result of irreversible inhibition of acetylcholine (ACh) release at the presynaptic nerve terminal of the body's neuromuscular junctions (NMJs).
What does botulism do to nerves?
organisms. Botulism (“BOT-choo-liz-um”) is a rare but serious illness caused by a toxin that attacks the body's nerves and causes difficulty breathing, muscle paralysis, and even death. This toxin is made by Clostridium botulinum and sometimes Clostridium butyricum and Clostridium baratii bacteria.
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