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What toxin causes spastic paralysis?

【Expert answer】

Created: 2022-06-17 23:12:28

Any Q

Tetanus toxin is one of the most potent toxins known. It is the agent that causes spastic paralysis following infection of peripheral injuries with Clostridium tetani (a condition also known as 'lockjaw'). Tetanus toxin is a protein of about 150 kDa, comprising a light and a heavy chain.


What neurotoxin causes paralysis?

Botulinum Neurotoxins Cause Muscle Paralysis by Inhibiting Synaptic Transmission. The botulinum neurotoxins are synthesized by the Clostridium bacteria and excreted in the form of inert, 150-kDa polypeptides which, produced inside the human body or gaining direct access into it, enter nerve endings.

Does Clostridium botulinum cause spastic paralysis?

These are termed botulinum neurotoxins (BoNTs) and are responsible for botulism, a rare but often severe disease with a high lethality rate. In contrast, C. tetani synthesizes a related neurotoxin called tetanus toxin (TeNT), which causes a dramatic spastic paralysis.

Does botulism cause flaccid or spastic paralysis?

Botulism is a disease caused by this neurotoxin (specifically A, B, E, or F type neurotoxin); symptoms include a flaccid paralysis (weakness or slackness) in various muscles.

What toxin inhibits muscle contraction causing flaccid paralysis?

Intramuscular administration of botulinum toxin acts at the neuromuscular junction to cause muscle paralysis by inhibiting the release of acetylcholine from presynaptic motor neurons.

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How does botulinum toxin lead to muscle paralysis?
Is botulism flaccid paralysis?

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